Tay-Sachs Disease Associated with Precocious Puberty


(T. T.) Dept. of Pediatrics Toranomon Hospital 2-2-2 Toranomon Minato-ku, Tokyo 105 Japan


ABSTRACT. A girl with Tay-Sachs disease developed enlargement of the mammary glands at the age of 4 years and menstruation at the age of 6 years. It was demonstrated that the precocious puberty in this patient was due to the hypersecretion of gonadotropins.