Development of Anti-hGH Antibodies during Therapy with Authentic Human Growth Hormone

Authors


(K.L.) Kabi Pharmacia Peptide Hormones S-112 87 Stockholm Sweden

Abstract

ABSTRACT. Children treated with authentic human growth hormone (Genotropin) in clinical trials between 1985 and 1989 were tested for the presence of anti-hGH antibodies. The incidence of antibodies after 12 months of treatment was 4/373 (1.1%). Mean binding capacity was 0.07 mg/1. The results suggest that Genotropin has low immunogenicity.

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