γδ lymphocytes in mumps meningitis patients

Authors


A Bertotto, Department of Paediatrics, Perugia University Medical School, Policlinico-Monteluce, I-06100 Perugia, Italy

Abstract

Flowcytometric analysis on T-cell subpopulations in the blood and cerebrospinal fluid (CSF) of 10 children with mumps meningitis (MM) revealed that the proportion of lymphocytes which bore the γδ T-cell receptor for antigen was significantly higher in CSF than in autologous and heterologous blood samples. γδ T-cell values in CSF of MM patients were also significantly higher than those calculated in CSF specimens from nine children with non-inflammatory neurological disorders. Whether and how the expanded CSF γδ T-lymphocyte subset, either CD8 + or double-negative (CD4-/CD8-), contributes to the eradication of mumps virus infection from the central nervous system represents a central focus of our ongoing research.

Ancillary