Those results were presented in part at the annual meeting of the American Pediatric Society and the Society for Pediatric Research, 1992.
Respiratory syncytial virus infection enhances the response to laryngeal chemostimulation and inhibits arousal from sleep in young lambs*
Article first published online: 21 JAN 2008
Volume 85, Issue 7, pages 789–797, July 1996
How to Cite
Lindgren, C., Lin, J., Graham, B., Gray, M., Parker, R. and Sundell, H. (1996), Respiratory syncytial virus infection enhances the response to laryngeal chemostimulation and inhibits arousal from sleep in young lambs. Acta Paediatrica, 85: 789–797. doi: 10.1111/j.1651-2227.1996.tb14153.x
- Issue published online: 21 JAN 2008
- Article first published online: 21 JAN 2008
- Received June 23, 1995. Accepted in revised form Feb. 19, 1996
- laryngeal chemoreceptors;
- respiratory syncytial virus;
- sudden infant death syndrome
To evaluate the effect of respiratory syncytial virus (RSV) infection on the response to laryngeal chemostimulation (LCS) with water, five lambs were inoculated with human RSV and three lambs were given control media at an age of 3-5 days. During RSV infection, LCS resulted in increased inhibition of minute ventilation and delayed recovery of regular breathing. Sleep further increased the response, and arousal was less likely to occur in active sleep. Two of the five infected lambs needed resuscitation after LCS when arousal was absent. Histological studies showed bronchiolitis and pneumonitis. Laryngeal tastebud morphology was unchanged at 8 days after inoculation. However, infected lambs had disrupted tastebuds 4-6 weeks after infection. Failure to arouse and to terminate reflex apnea may play a role in the pathogenesis of the sudden infant death syndrome associated with respiratory tract infection.