Simultaneous stimulation of growth hormone, adrenocorticotropin and cortisol with L-dopa/L-carbidopa and propranolol in children of short stature
Article first published online: 2 JAN 2007
Volume 89, Issue 4, pages 442–446, April 2000
How to Cite
Philippi, H., Pohlenz, J., Grimm, W., Koffler, T. and Schönberger, W. (2000), Simultaneous stimulation of growth hormone, adrenocorticotropin and cortisol with L-dopa/L-carbidopa and propranolol in children of short stature. Acta Paediatrica, 89: 442–446. doi: 10.1111/j.1651-2227.2000.tb00081.x
- Issue published online: 2 JAN 2007
- Article first published online: 2 JAN 2007
- Received Jan. 15, 1999; revisions received July 28 and Nov. 29, 1999; accepted Dec. 4, 1999
- growth hormone;
- modified L-dopa-test;
- pituitary hormone stimulation
In 59 otherwise healthy children of short stature, the simultaneous response of growth hormone, cortisol and plasma adrenocorticotropin (ACTH) to L-dopa/L-carbidopa and propranolol at 45 and 90min after administration were investigated. A growth hormone response of 10 μg/l or higher was considered positive. The definition of a positive cortisol response included either a hormone increase of at least 193 nmol/l or a peak hormone level of at least 497 nmol/l. The ACTH increase had to be fourfold above 11 pmol/l to be considered positive. In the 59 investigated children, the median basal growth hormone levels increased from 1.35 p.g/l to 18.05 ug/l and 10.15 p.g/l at 45 and 90 min after stimulation (p <0.05). The median cortisol levels rose from 242 nmol/l to 439 nmol/l and 612 pmol/l, and the corresponding median ACTH levels from 2.94 pmol/l to 9.63 pmol/l and 11.13 pmol/l at 45 and 90 min after stimulation. Significant positive hormone response rates were 88.1% for growth hormone, 88.1% for cortisol and 69% for ACTH. These results could be attributed to the enhanced stimulating effect of the additional administration of L-carbidopa and propranolol.
We conclude that the administration of L-dopa/L-carbidopa and propranolol is useful for the simultaneous evaluation of growth hormone, cortisol and ACTH secretion in children of short stature.