Dietary supplementation of long-chain polyunsaturated fatty acids in preterm infants: effects on cerebral maturation

Authors

  • G van Wezel-Meijler,

    Corresponding author
    1. Department of Paediatrics, Subdivisions of Neonatology, Free University Medical Centre, Amsterdam, The Netherlands
      G van Wezel-Meijler, Department of Paediatrics, Subdivision of Neonatology, Leiden University Medical Centre, P.O. Box 9600, NL-2300 RC Leiden, The Netherlands (Tel. +31 71 5262 909, fax. +31 71 5248 199, e-mail. G.van_Wezel-Meijler@lumc.nl)
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  • MS van der Knaap,

    1. Child Neurology, Free University Medical Centre, Amsterdam, The Netherlands
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  • J Huisman,

    1. Departments of Medical Psychology, Free University Medical Centre, Amsterdam, The Netherlands
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  • EJ Jonkman,

    1. Clinical Neurophysiology, Free University Medical Centre, Amsterdam, The Netherlands
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  • J Valk,

    1. Radiology, Free University Medical Centre, Amsterdam, The Netherlands
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  • HN Lafeber

    1. Department of Paediatrics, Subdivisions of Neonatology, Free University Medical Centre, Amsterdam, The Netherlands
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G van Wezel-Meijler, Department of Paediatrics, Subdivision of Neonatology, Leiden University Medical Centre, P.O. Box 9600, NL-2300 RC Leiden, The Netherlands (Tel. +31 71 5262 909, fax. +31 71 5248 199, e-mail. G.van_Wezel-Meijler@lumc.nl)

Abstract

Aim: To study the influence of dietary-supplied long-chain polyunsaturated fatty acids on structural brain maturation in preterm infants and to investigate parameters of functional brain development, relating them to structural maturation. Other studies have suggested that dietary supplementation of long-chain polyunsaturated fatty acids in preterm infants may enhance their visual development. The influence on structural brain development has never been evaluated. Methods: In a prospective, double-blind study, 42 formula-fed premature infants were randomized to be fed either a standard preterm formula without long-chain polyunsaturated fatty acids or an identical formula supplemented with docosahexaenoic acid (0.015 g/100 ml) and arachidonic acid (0.031 g/100ml). Infants with significant cerebral damage, retinopathy, chronic disease or feeding problems were excluded. Follow-up was focused on assessment of cerebral myelination by MRI. Psychomotor, mental and visual development was analysed and flash-visual evoked potentials were recorded. Results: It was found that progress of myelination, mental and motor development and latencies of visual evoked potentials were not positively influenced by supplementation of long-chain polyunsaturated fatty acids. At each test age, visual acuity was slightly better in the supplemented infants than in the non-supplemented infants, but the difference never reached significance level

Conclusion: Supplementation of long-chain polyunsaturated fatty acids did not have a demonstrable positive influence on structural brain maturation. Related to this finding, in this small cohort of preterm infants without significant neurological damage, sample size being restricted by strict inclusion criteria and MRI procedures, no significant positive effects were found on psychomotor, mental and visual development.

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