Randomized controlled trial of intrapleural streptokinase in empyema thoracis in children
Article first published online: 2 JAN 2007
Volume 93, Issue 11, pages 1443–1445, November 2004
How to Cite
Singh, M., Mathew, J., Chandra, S., Katariya, S. and Kumar, L. (2004), Randomized controlled trial of intrapleural streptokinase in empyema thoracis in children. Acta Paediatrica, 93: 1443–1445. doi: 10.1111/j.1651-2227.2004.tb02626.x
- Issue published online: 2 JAN 2007
- Article first published online: 2 JAN 2007
- Received Jan. 28, 2004; revision received Mar. 29, 2004; accepted Apr. 10, 2004
Aim: To compare intrapleural streptokinase and placebo in paediatric empyema. Methods: Children with empyema greater than stage 5 received intrapleural streptokinase (n= 19) or normal saline (n= 21) along with intercostal drainage. Clinical and serial sonographic outcomes were compared. Results: Although there was no difference in clinical and sonographic outcome, none of the children with stage 7 empyema (multi-loculated empyema) who received streptokinase developed pleural thickening 30 d later.
Conclusion: There is no short-term clinical benefit of intrapleural streptokinase in paediatric empyema; this therapy may be reserved for those with stage 7 empyema to prevent pleural thickening in the long term.