• Adolescence;
  • antipsychotic agents;
  • children;
  • hyperprolactinaemia;
  • prolactinoma

Aim: To demonstrate that hyperprolactinaemia and/or prolactinoma occur in association with antipsychotic medication use. Methods: Three case studies of patients with markedly elevated serum prolactin level (<132 μg/1); either antipsychotic medication induced or as a consequence of a prolactinoma.

Conclusion: The management and investigation of children with markedly elevated serum prolactin levels remains poorly defined. In our case series, two patients were found to have prolactinomas. We suggest that paediatric patients with serum prolactin level above 50 μg/1 in males and 70 μg/1 in females, regardless of any antipsychotic medication use, receive magnetic resonance imaging to exclude prolactinoma.