Evidence-based therapy in neonatology: distilling the evidence and applying it in practice*


  • JC Sinclair

    Corresponding author
    1. Departments of Pediatrics and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada; Center for Clinical Research and Evidence-based Medicine, University of Texas Medical School at Houston, Houston, Texas, USA
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  • *

    This paper is based on the presentation of John Sinclair on 17 March 2004 when he received the Rosén von Rosenstein award (Editor's note).

John C Sinclair, McMaster University Medical Centre, Room 3N11F, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5 (Tel. +1 905 521 2100 ext. 75611, fax. +1 905 521 5007, e-mail. sinclair@mcmaster.ca)


Abstract: Three aspects of the role of clinical evidence in guiding therapy in the field of neonatology are presented: 1) what is embodied in the concept “evidence-based medicine”? 2) the contribution of the Cochrane Collaboration and its Neonatal Review Group in summarizing and disseminating evidence, in the form of systematic reviews of randomized controlled trials, concerning the benefits and risks of therapies in the field of neonatology; 3) approaches to bridging the gap between the evidence per se and the uptake and application of that evidence in practice.