Tight junctions, leaky intestines, and pediatric diseases
Article first published online: 2 JAN 2007
Volume 94, Issue 4, pages 386–393, April 2005
How to Cite
Liu, Z., Li, N. and Neu, J. (2005), Tight junctions, leaky intestines, and pediatric diseases. Acta Paediatrica, 94: 386–393. doi: 10.1111/j.1651-2227.2005.tb01904.x
- Issue published online: 2 JAN 2007
- Article first published online: 2 JAN 2007
- Received 01 January 2004; Revised 04 May 2004; Accepted 10 May 2004
- tight junctions;
- leaky gut
Background: Tight junctions (TJs) represent the major barrier within the paracellular pathway between intestinal epithelial cells. Disruption of TJs leads to intestinal hyperpermeability (the so-called “leaky gut”) and is implicated in the pathogenesis of several acute and chronic pediatric disease entities that are likely to have their origin during infancy. Aim: This review provides an overview of evidence for the role of TJ breakdown in diseases such as systemic inflammatory response syndrome (SIRS), inflammatory bowel disease, type 1 diabetes, allergies, asthma, and autism.
Conclusion: A better basic understanding of this structure might lead to prevention or treatment of these diseases using nutritional or other means.