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Tight junctions, leaky intestines, and pediatric diseases
Article first published online: 2 JAN 2007
DOI: 10.1111/j.1651-2227.2005.tb01904.x
1651-2227/asset/cover.gif?v=1&s=587e9b334e01b5328ef56d6ab5552a09f530e683 "Acta Paediatrica")
Additional Information
How to Cite
Liu, Z., Li, N. and Neu, J. (2005), Tight junctions, leaky intestines, and pediatric diseases. Acta Paediatrica, 94: 386–393. doi: 10.1111/j.1651-2227.2005.tb01904.x
Publication History
- Issue published online: 2 JAN 2007
- Article first published online: 2 JAN 2007
- Received 01 January 2004; Revised 04 May 2004; Accepted 10 May 2004
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Keywords:
- Intestines;
- tight junctions;
- leaky gut
Abstract
Background: Tight junctions (TJs) represent the major barrier within the paracellular pathway between intestinal epithelial cells. Disruption of TJs leads to intestinal hyperpermeability (the so-called “leaky gut”) and is implicated in the pathogenesis of several acute and chronic pediatric disease entities that are likely to have their origin during infancy. Aim: This review provides an overview of evidence for the role of TJ breakdown in diseases such as systemic inflammatory response syndrome (SIRS), inflammatory bowel disease, type 1 diabetes, allergies, asthma, and autism.
Conclusion: A better basic understanding of this structure might lead to prevention or treatment of these diseases using nutritional or other means.