Collagenous colitis and eosinophilic gastritis in a 4-year old girl: a case report and review of the literature
Article first published online: 20 AUG 2007
©2007 The Author(s)/Journal Compilation © 2007 Foundation Acta Pædiatrica/Acta Pædiatrica
Volume 96, Issue 9, pages 1365–1367, September 2007
How to Cite
Benchimol, E. I., Kirsch, R., Viero, S. and Griffiths, A. M. (2007), Collagenous colitis and eosinophilic gastritis in a 4-year old girl: a case report and review of the literature. Acta Paediatrica, 96: 1365–1367. doi: 10.1111/j.1651-2227.2007.00424.x
- Issue published online: 20 AUG 2007
- Article first published online: 20 AUG 2007
- Received 7 May 2007; revised 31 May 2007; accepted 13 June 2007.
- Chronic diarrhoea;
- Collagenous colitis;
- Eosinophilic gastroenteritis;
- Lymphocytic colitis;
Collagenous colitis (CC), a form of microscopic colitis, is characterized by a thick subepithelial collagen layer in the colon in the presence of chronic nonbloody watery diarrhoea and macroscopically normal-appearing colonic mucosa. Typically affecting elderly adults, CC is rare in children with only 12 cases previously reported in the literature. We report the case of a 4-year-old girl with CC associated with eosinophilic gastritis, which was clinically responsive to treatment with ketotifen, a benzocycloheptathiophene derivative, and H1 class of antihistamine that stabilizes mast cells and potentially impairs eosinophil migration to target organs. We review the published cases of paediatric-onset CC and summarize the links between eosinophils and CC in the clinical and basic science literature.
Conclusion: CC is a rare cause of chronic diarrhoea in children and may relate to mast cell and eosinophil activity.