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Vincristine, an efficacious alternative for diffuse neonatal haemangiomatosis


Máximo Vento, PhD, MD, Professor in Pediatrics, Servicio de Neonatología, Hospital Universitario Materno Infantil La Fe, Avenida de Campanar 21, E46009 Valencia, Spain. Tel: + 34-96-3862791 | Fax: +34-96-1973408 | Email:


Diffuse neonatal haemangiomatosis (DNH) is an uncommon condition characterized by multiple cutaneous and visceral haemangiomas frequently causing severe complications. Corticosteroids constitute the first therapeutic line; however, when they fail, other alternatives are available, provided possible side effects are closely monitored during and after treatment. We present a case of life-threatening DNH, non-responsive to corticosteroids, successfully treated with Vincristine with minor side effects. We conclude that Vincristine is a valid alternative in corticosteroid-resistant DNH.