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C-reactive protein in the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome
Article first published online: 12 OCT 2007
DOI: 10.1111/j.1651-2227.2007.00499.x
©2007 The Author(s)/Journal Compilation © 2007 Foundation Acta Pædiatrica/Acta Pædiatrica
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How to Cite
Førsvoll, J. A. and Øymar, K. (2007), C-reactive protein in the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. Acta Paediatrica, 96: 1670–1673. doi: 10.1111/j.1651-2227.2007.00499.x
Publication History
- Issue published online: 12 OCT 2007
- Article first published online: 12 OCT 2007
- Received 28 April 2007; revised 15 June 2007; accepted 1 August 2007.
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Keywords:
- Children;
- C-reactive protein;
- Periodic fever;
- PFAPA syndrome
Abstract
Aims: To evaluate levels of C-reactive protein (CRP) during febrile episodes in children with periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Methods: All CRP values during typical episodes of fever in children diagnosed with PFAPA during a 3 years period were retrospectively registered.
Results: In 16 children with PFAPA, a total of 87 CRP values were registered during 38 episodes of fever. The mean of the maximum CRP during each episode was 185 mg/L (SD: 69.4, range: 45–322). Values of CRP were elevated throughout the whole period of fever, with higher values on days 2–4 compared to day 1.
Conclusion: Levels of CRP are substantially increased during febrile episodes in children with PFAPA. High levels of CRP may suggest a role for immunological mechanisms in PFAPA, and may raise the suspicion of PFAPA when measured in children with periodic fever of unknown origin.