Ferritin levels in children with severe sepsis and septic shock
Article first published online: 12 NOV 2007
Volume 96, Issue 12, pages 1829–1831, December 2007
How to Cite
Garcia, P. C. R., Longhi, F., Branco, R. G., Piva, J. P., Lacks, D. and Tasker, R. C. (2007), Ferritin levels in children with severe sepsis and septic shock. Acta Paediatrica, 96: 1829–1831. doi: 10.1111/j.1651-2227.2007.00564.x
- Issue published online: 12 NOV 2007
- Article first published online: 12 NOV 2007
- Received 31 May 2007; revised 10 September 2007; accepted 17 September 2007.
- Intensive care;
- Iron metabolism;
Aim: To evaluate serum ferritin level in children with severe sepsis and septic shock and its association with mortality.
Method: A cohort study of 36 children aged 1 month–16 years with severe sepsis or septic shock requiring intensive care was conducted. Serum ferritin levels were measured at the time of diagnosis of sepsis and a ferritin index (FI = observed serum ferritin divided by the upper limit of normal ferritin for age and gender) was calculated.
Results: The median age (range) of the children was 6 (2–100) months. Ferritin was <200 ng/mL in 13 children, 200–500 ng/mL in 11 children and >500 ng/mL in 12 children. The mortality associated with these groups was 23%, 9% and 58%, respectively. A ferritin >500 ng/mL was associated with a 3.2 (1.3–7.9) relative risk of death (p = 0.01). FI of 1.7 was the best cutoff value for identifying those who died. In a logistic regression analysis, ferritin level and PRISM were independently associated with mortality.
Conclusions: Ferritin is raised in children with septic shock and high ferritin level is associated with poorer outcome.