Terlipressin as rescue treatment of refractory shock in a neonate
Article first published online: 28 FEB 2008
©2008 The Author(s)/Journal Compilation © 2008 Foundation Acta Pædiatrica/Acta Pædiatrica
Volume 97, Issue 4, pages 500–501, April 2008
How to Cite
Filippi, L., Poggi, C., Serafini, L. and Fiorini, P. (2008), Terlipressin as rescue treatment of refractory shock in a neonate. Acta Paediatrica, 97: 500–501. doi: 10.1111/j.1651-2227.2008.00681.x
- Issue published online: 28 FEB 2008
- Article first published online: 28 FEB 2008
- Received 20 September 2007; revised 12 December 2007; accepted 21 December 2007.
- Systemic inflammatory response syndrome;
Patients with septic shock may develop refractory hypotension despite maximal inotropic support with impairment of clinical outcome. Terlipressin, a long-acting vasopressin analogue, is reported to be effective as rescue treatment of refractory septic shock in adult and paediatric patients, while clinical experience in neonates is definitely scarce. We report a neonate with systemic inflammatory response syndrome after surgery for abdominal neuroblastoma who received terlipressin as rescue treatment after failure of volume load and catecholamines. Terlipressin promptly reversed hypotension and improved tissue perfusion without adverse effects.
Conclusion: Terlipressin appears an effective rescue treatment in patients with refractory vasodilatory septic shock. Further studies are required to assess its efficacy and safety in neonatal population.