Maternal tobacco smoking, nicotine replacement and neurobehavioural development
Article first published online: 28 JUN 2008
©2008 The Author(s)/Journal Compilation ©2008 Foundation Acta Pædiatrica/Acta Pædiatrica
Volume 97, Issue 10, pages 1331–1337, October 2008
How to Cite
Pauly, J. R. and Slotkin, T. A. (2008), Maternal tobacco smoking, nicotine replacement and neurobehavioural development. Acta Paediatrica, 97: 1331–1337. doi: 10.1111/j.1651-2227.2008.00852.x
- Issue published online: 2 SEP 2008
- Article first published online: 28 JUN 2008
- Received 20 February 2008; revised 8 April 2008; accepted 14 April 2008.
Vol. 98, Issue 1, 208, Article first published online: 9 DEC 2008
- Nicotinic receptor;
- Nicotine replacement therapy;
- Sudden infant death syndrome
The adverse effects of prenatal cigarette smoke exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, approximately 25% of women of childbearing age currently smoke cigarettes, and only a small percentage of these individuals quit after learning of their pregnancy. Women interested in smoking cessation during pregnancy have a number of options, including behavioural and pharmacological aids, but nicotine replacement therapy (NRT) is by far the most common approach. While NRT avoids exposure to the myriad compounds present in tobacco smoke, nicotine itself causes damage to the developing nervous system. The purpose of this article is to review the detrimental effects of developmental tobacco smoke exposure on short- and long-term outcomes with particular emphasis on neurobehavioural consequences. In conclusion based on the clear, adverse effects of nicotine on brain development observed in human and animal studies, we suggest that safer alternatives for smoking cessation in pregnancy are badly needed.