Quantitative ultrasound (QUS): a useful tool for monitoring bone health in preterm infants?
Article first published online: 29 AUG 2008
©2008 The Author(s)/Journal Compilation ©2008 Foundation Acta Pædiatrica/Acta Pædiatrica
Volume 97, Issue 12, pages 1625–1630, December 2008
How to Cite
Fewtrell, M., Loh, K., Chomtho, S., Kennedy, K., Hawdon, J. and Khakoo, A. (2008), Quantitative ultrasound (QUS): a useful tool for monitoring bone health in preterm infants?. Acta Paediatrica, 97: 1625–1630. doi: 10.1111/j.1651-2227.2008.00992.x
- Issue published online: 6 NOV 2008
- Article first published online: 29 AUG 2008
- Received 25 January 2008; revised 18 April 2006; accepted 21 July 2008.
Preterm infants are at risk of osteopenia and metabolic bone disease (MBD) of prematurity. There is a need for simple, reliable methods to detect and monitor this condition.
Aims: The aims were first to describe longitudinal changes in speed of sound (SOS) measured using quantitative ultrasound (QUS; Sunlight Omnisense, Israel) in preterm neonates: and second to determine whether SOS predicts the development of MBD.
Methods: SOS was measured in the tibia in 99 preterm infants (mean (SD)) gestation 29.7 (3.6) weeks; birthweight 1340 (550) g, with longitudinal measurements in 75. SOS z-scores were generated for gestation and sex. Clinical data were recorded.
Results: Baseline SOS (but not SOS z-score) was positively associated with gestational age. SOS and SOS z-score fell with age. In multivariate models, peak ALP, minimum phosphate concentrations and markers of illness severity were not predictors of the fall in SOS z-score, and baseline SOS measurements did not predict the development of high peak ALP or low phosphate.
Interpretation: Speed of sound measurements fell with age in all infants, but we found no evidence that this measurement could predict biochemical indicators of MBD. We cannot exclude the possibility that this technique could be useful in monitoring the response to interventions designed to improve bone health in this population.