Hypertrophic cardiomyopathy and transposition of great arteries associated with maternal diabetes and presumed gestational diabetes
Article first published online: 4 SEP 2008
©2008 The Author(s)/Journal Compilation ©2008 Foundation Acta Pædiatrica/Acta Pædiatrica
Volume 97, Issue 12, pages 1755–1757, December 2008
How to Cite
Chaudhari, M., Brodlie, M. and Hasan, A. (2008), Hypertrophic cardiomyopathy and transposition of great arteries associated with maternal diabetes and presumed gestational diabetes. Acta Paediatrica, 97: 1755–1757. doi: 10.1111/j.1651-2227.2008.01022.x
- Issue published online: 6 NOV 2008
- Article first published online: 4 SEP 2008
- Received 3 June 2008; revised 22 July 2008; accepted 11 August 2008.
- Congenital heart disease;
- Diabetes mellitus;
- Hypertrophic cardiomyopathy;
- Paediatrics transposition of the great arteries
Maternal diabetes mellitus affects the foetal heart both structurally and functionally. In early gestation, it has a teratogenic effect causing defects of primary cardiogenesis. In late gestation, it causes a unique form of hypertrophic cardiomyopathy. We report an infant of a diabetic mother and an infant where there was presumed gestational diabetes during the pregnancy who presented with combined severe hypertrophic cardiomyopathy and complex transposition of the great arteries. This rare combination of structural and functional cardiac abnormalities reflects the different mechanisms and timings of injury that may occur to the foetal heart in association with maternal diabetes and has not been previously reported. The combination has significant implications regarding medical and surgical management, and necessitates prolonged supportive therapy whilst awaiting regression of the hypertrophic cardiomyopathy followed by delayed arterial switch operation.
Conclusion: We describe two infants with the unusual combination of both hypertrophic cardiomyopathy and transposition of the great arteries. One was an infant of a diabetic mother, and the second was associated with presumed gestational diabetes.