Multiple viral respiratory pathogens in children with bronchiolitis
Article first published online: 10 SEP 2008
©2008 The Author(s)/Journal Compilation ©2008 Foundation Acta Pædiatrica/Acta Pædiatrica
Volume 98, Issue 1, pages 123–126, January 2009
How to Cite
Stempel, H. E., Martin, E. T., Kuypers, J., Englund, J. A. and Zerr, D. M. (2009), Multiple viral respiratory pathogens in children with bronchiolitis. Acta Paediatrica, 98: 123–126. doi: 10.1111/j.1651-2227.2008.01023.x
- Issue published online: 9 DEC 2008
- Article first published online: 10 SEP 2008
- Received 10 April 2008; accepted 13 August 2008.
- Respiratory syncytial virus;
- Viral infections
Aim: The aim of the study was to describe the frequency of viral pathogens and relative frequency of co-infections in nasal specimens obtained from young children with bronchiolitis receiving care at a children's hospital.
Methods: We conducted a study of nasal wash specimens using real-time PCR and fluorescent-antibody assay results from children less than two with an ICD-9-CM code for bronchiolitis. All specimens were collected for clinical care at Children's Hospital in Seattle, WA, USA, during the respiratory season from October 2003 to April 2004.
Results: Viruses were detected in 168 (93%) of the 180 children with bronchiolitis. A single virus was identified in 127 (71%) children and multiple viruses in 41 (23%). Respiratory syncytial virus (RSV) was the most common virus detected (77%), followed by adenovirus (15%), human metapneumovirus (11%), coronavirus (8%), parainfluenza (6%) and influenza (1%). Of the 139 samples with RSV detected, 34 (24%) were co-infected with another viral pathogen.
Conclusion: Molecular diagnostic techniques identified a high frequency of viruses and viral co-infections among children evaluated for bronchiolitis. Further study of the role of viral pathogens other than RSV and co-infections with RSV in children with bronchiolitis appears warranted.