SEARCH

SEARCH BY CITATION

Keywords:

  • Bradford hill criteria;
  • Causality;
  • Evidence synthesis;
  • Medicines for children;
  • Pharmacoepidemiology

Abstract

Background: Data on safety of medicines in children typically arises from various sources, rendering assessment of causality challenging.

Methods: We outline these sources, together with their strengths and weaknesses. Bradford Hill proposed criteria for assessment of causality of observed associations; we explore their utility in this context.

Conclusion: Collaborations between clinicians, epidemiologists and clinical pharmacologists, making intelligent use of both older and newer methodologies, can help make the use of medicines in children safer.