Severe psychomotor and metabolic damages caused by a mutant thyroid hormone receptor alpha 1 in mice: can patients with a similar mutation be found and treated?

Authors


Correspondence
Prof. Björn Vennström, Department of Cell &
Molecular Biology, Karolinska Institutet, von Eulers
väg 3, 17177 Stockholm, Sweden.
Tel: +46-8-52487350 |
Fax: +46-8-348135 |
Email: Bjorn.Vennstrom@ki.se

Abstract

Individuals suffering from the resistance to thyroid hormone syndrome (RTH) have a mutation in thyroid hormone receptor (TR) β. Surprisingly, no patient with a mutation in TRα1 has been found. To facilitate their identification, animal models with a RTH-like mutation in TRα1 have been generated. The mutations introduced into the mouse decrease affinity to ligand, resulting in a ‘receptor-mediated hypothyroidism’ in tissues expressing the mutant receptor: brain, heart and bone. The mice present minor perturbances in thyroid hormone homeostasis, but show major aberrancies in postnatal development, psychomotor behaviour and metabolism. These parameters are akin to those seen in endemic cretinism and untreated congenital hypothyroidism. Treatment of the mice with high doses of triiodothyronine leads to normalization or amelioration of the dysfunctions when applied at adequate developmental periods.

Conclusion: Our studies on mice suggest the existence of a potentially debilitating disease caused by a mutant TRα1, and provide insights for identification and treatment of corresponding patients.

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