Regional variation in celiac disease risk within Sweden revealed by the nationwide prospective incidence register
Article first published online: 21 OCT 2008
©2008 The Author(s)/Journal Compilation ©2008 Foundation Acta Pædiatrica/Acta Pædiatrica
Volume 98, Issue 2, pages 337–342, February 2009
How to Cite
Olsson, C., Stenlund, H., Hörnell, A., Hernell, O. and Ivarsson, A. (2009), Regional variation in celiac disease risk within Sweden revealed by the nationwide prospective incidence register. Acta Paediatrica, 98: 337–342. doi: 10.1111/j.1651-2227.2008.01086.x
- Issue published online: 12 JAN 2009
- Article first published online: 21 OCT 2008
- Received 19 June 2008; revised 05 September 2008; accepted 18 September 2008.
- Celiac disease;
Aim: To determine if there is any regional celiac disease (CD) risk variation in the Swedish childhood population.
Methods: Prospective nationwide Swedish incidence register of CD in children 0–15 years of age, with the present analysis covering the period from 1998 to 2003. ESPGHAN diagnostic criteria for CD were used. Regions were classified according to the Nomenclature of Territorial Units for Statistics. The incidence rate for each region, gender, age group and year of diagnosis was calculated.
Results: A regional variation in CD risk was demonstrated. The childhood populations in ‘West Sweden’ and ‘Småland and the islands’, situated in the southern part of the country, had a significantly higher incidence rate compared to in ‘North Middle Sweden’ and ‘Stockholm’, situated in the central part. This regional variation was not explained by variations in risk by gender, age at diagnosis or year of diagnosis.
Conclusion: The Swedish regional variation in CD risk supports multifactorial disease aetiology. Continued efforts are warranted to define factors, besides gluten exposure, that modulate CD risk.