Effects of topiramate on weight and metabolism in children with epilepsy

  1. Hai-feng Li1,
  2. Yan Zou2,
  3. Zhe-zhi Xia1,
  4. Feng Gao1,
  5. Jian-hua Feng1,
  6. Cui-wei Yang1

Article first published online: 8 JUN 2009

DOI: 10.1111/j.1651-2227.2009.01349.x

Issue

Acta Paediatrica

Acta Paediatrica

Volume 98, Issue 9, pages 1521–1525, September 2009

Additional Information

How to Cite

Li, H.-f., Zou, Y., Xia, Z.-z., Gao, F., Feng, J.-h. and Yang, C.-w. (2009), Effects of topiramate on weight and metabolism in children with epilepsy. Acta Paediatrica, 98: 1521–1525. doi: 10.1111/j.1651-2227.2009.01349.x

Author Information

  1. 1

    The Children's Hospital Zhejiang University School of Medicine, Hangzhou, China

  2. 2

    Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China

*Zhe-zhi Xia, Mmed, 57 Zhugan Lane, Yanan Road, Hangzhou 310003 People's Republic of China. Tel.: +86-571-87061007 | Fax: +86-571-87115099 | Email: Leehf0571@gmail.com

Publication History

  1. Issue published online: 27 JUL 2009
  2. Article first published online: 8 JUN 2009
  3. Received 26 December 2008; revised 31 March 2009; accepted 17 April 2009.

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Keywords:

  • Adiponectin;
  • Children;
  • Epilepsy;
  • Topiramate

Abstract

Aim:  To explore the mechanism of topiramate-induced weight loss in epilepsy children by monitoring metabolism indices.

Methods: Children with epilepsy were treated with topiramate at their first clinical visit. Metabolism indices including body mass index (BMI) and its SD scores, leptin, adiponectin, leptin/adiponectin (L/A), lipid profile-insulin and Homeostasis Model Assessments (HOMA) index were collected before and after treatment.

Results:  Topiramate treatment significantly reduced L/A (t = 2.156, p = 0.031), and markedly increased the serum level of adiponectin (t = 3.124, p = 0.002). Moreover, there were no relationships between the metabolism indices and dosages of topiramate (p > 0.05).

Conclusion:  Our studies find that topiramate treatment in epilepsy children increases energy metabolism, resulting in weight loss. It has been demonstrated that adiponectin play a significant role in metabolic regulations.

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