Visual neurophysiological dysfunction in infants exposed to hydroxychloroquine in utero
Article first published online: 4 JUN 2009
© 2009 The Author(s)/Journal Compilation © 2009 Foundation Acta Pædiatrica
Volume 98, Issue 9, pages 1500–1503, September 2009
How to Cite
Renault, F., Flores-Guevara, R., Renaud, C., Richard, P., Vermersch, A. and Gold, F. (2009), Visual neurophysiological dysfunction in infants exposed to hydroxychloroquine in utero. Acta Paediatrica, 98: 1500–1503. doi: 10.1111/j.1651-2227.2009.01379.x
- Issue published online: 27 JUL 2009
- Article first published online: 4 JUN 2009
- Received 4 February 2009; revised 14 April 2009; accepted 12 May 2009
- Visual evoked potentials
Aim: Hydroxychloroquine therapy during pregnancy is thought to be safe for foetuses. Normal visual function has been showed on clinical grounds in infants exposed in utero to hydroxychloroquine, but there are few visual neurophysiological data. Our study was designed to assess retina and visual pathways using electroretinogram and visual evoked potentials in a series of infants born to mothers treated by hydroxychloroquine for connective tissue diseases.
Methods: Twenty-one infants (3–7 months of age) were consecutively examined between June 2002 and May 2007. Full-field electroretinogram was recorded by contact lens electrodes and visual evoked potentials were recorded by occipital surface electrodes using flash stimulation in mesopic condition. Analysis was focused on the amplitudes and latencies of the a- and b-waves of electroretinogram and the latency of the P100 component of visual evoked potentials.
Results: Electroretinogram abnormalities were detected in six infants, associated with delayed visual evoked potentials in four of them.
Conclusion: Early electroretinogram and visual evoked potentials testing evidenced neurophysiological visual disturbances in a subset of infants born to mothers treated by hydroxychloroquine. Systematic clinical and neurophysiological vision testing during childhood is needed to detect possible consequences of antenatal exposure to hydroxychloroquine.