Insulin resistance among Brazilian schoolchildren: association with risk factors for cardiovascular diseases

  1. MWL Strufaldi,
  2. EMK Da Silva,
  3. RF Puccini

Article first published online: 30 JUN 2009

DOI: 10.1111/j.1651-2227.2009.01411.x

Issue

Acta Paediatrica

Acta Paediatrica

Volume 98, Issue 10, pages 1646–1650, October 2009

Additional Information

How to Cite

Strufaldi, M., Da Silva, E. and Puccini, R. (2009), Insulin resistance among Brazilian schoolchildren: association with risk factors for cardiovascular diseases. Acta Paediatrica, 98: 1646–1650. doi: 10.1111/j.1651-2227.2009.01411.x

Author Information

  1. Department of Pediatrics, School of Medicine, Federal University of São Paulo, São Paulo, Brazil

*RF Puccini, Department of Pediatrics, Federal University of São Paulo, Rua Botucatu, 598 São Paulo 04023-062, Brazil. Tel: +55 11 5539 1097 | Fax: +55 11 5539 0107 | Email: mwany@uol.com.br; pediatria@pediatria.epm.br

Publication History

  1. Issue published online: 1 SEP 2009
  2. Article first published online: 30 JUN 2009
  3. Received February 2009; revised 2 April 2009; accepted 5 June 2009.

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Keywords:

  • Cardiovascular risk factors;
  • Children;
  • Insulin resistance

Abstract

Aim:  Our purpose was to evaluate Insulin Resistance (IR) and its association with risk factors for cardiovascular diseases (CVDs) among 161 (6- to 10-year-old) schoolchildren.

Methods:  This two-stage cross-sectional study evaluated: BMI, blood pressure, personal history (birth weight) and family history of CVDs. Children with at least one of the following criteria participated in the second stage: obesity, personal or family history. Insulin resistance was determined using Homeostasis Model Assessment (HOMA).

Results:  The HOMA distribution in terciles showed mean values for the first, second and third tercile of 0.41, 0.79 and 2.11 respectively. The HOMA distribution in the third tercile demonstrated statistically significant associations with overweight/obesity (p = 0.007), hypertension (p = 0.008) and low HDL (p = 0.02). Analysis of mean birth weight in each tercile and between terciles did not present any positive correlation (p = 0.213).

Conclusion:  Higher levels of HOMA (IR) were positively associated with risk factors for CVD among schoolchildren.

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