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Cognitive outcome at 2 years of age in Finnish infants with very low birth weight born between 2001 and 2006

Authors

  • P Munck,

    1. Department of Pediatrics, Turku University Hospital, Turku, Finland
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  • L Haataja,

    1. Department of Pediatric Neurology, Turku University Hospital, Turku, Finland
    2. Department of Medicine, University of Turku, Turku, Finland
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  • J Maunu,

    1. Department of Pediatric Neurology, Turku University Hospital, Turku, Finland
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  • R Parkkola,

    1. Department of Radiology, Turku University Hospital, Turku, Finland
    2. Turku PET Center, Turku University Hospital, Turku, Finland
    3. Department of Medicine, University of Turku, Turku, Finland
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  • H Rikalainen,

    1. Department of Radiology, Turku University Hospital, Turku, Finland
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  • H Lapinleimu,

    1. Department of Pediatrics, Turku University Hospital, Turku, Finland
    2. Department of Medicine, University of Turku, Turku, Finland
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  • L Lehtonen,

    1. Department of Pediatrics, Turku University Hospital, Turku, Finland
    2. Department of Medicine, University of Turku, Turku, Finland
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  • the PIPARI Study Group

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    • *

      The PIPARI Study Group includes Satu Ekblad, RN; Mikael Ekblad, medical student; Eeva Ekholm, MD, PhD; Leena Haataja, MD, PhD; Pentti Kero, MD, PhD; Riikka Korja, PhD; Harry Kujari, MD; Helena Lapinleimu MD, PhD; Liisa Lehtonen, MD, PhD; Annika Lind, MA; Hanna Manninen, MD; Jaakko Matomäki, MSc; Jonna Maunu, MD; Petriina Munck, MA; Pekka Niemi, PhD; Pertti Palo, MD, PhD; Riitta Parkkola, MD, PhD; Jorma Piha, MD, PhD; Liisi Rautava, MD; Päivi Rautava, MD, PhD; Milla Reiman, MD, PhD; Hellevi Rikalainen, MD, PhD; Katriina Saarinen, Physiotherapist; Elina Savonlahti, MD; Matti Sillanpää, MD, PhD; Suvi Stolt, PhD; Päivi Tuomikoski-Koiranen, RN; Anniina Väliaho, MA; and Tuula Äärimaa, MD, PhD.


P. Munck, Department of Pediatrics, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland. Tel: +358 50 525 4292 |
Fax: +358-2 313 1460 |
Email: petmun@utu.fi

Abstract

Aim:  To study cognitive outcome of premature, very low birth weight (VLBW) infants in relation to parental education and neonatal data.

Methods:  A regional cohort of 182 VLBW infants born between 2001 and 2006 was followed up. Brain ultrasounds (US) were examined serially until term age and brain magnetic resonance imaging at term age. Neurological status was examined systematically. Cognitive development was assessed using the Mental Developmental Index (MDI) of Bayley Scales at 2 years of corrected age. A total of 192 healthy full-term (FT) controls were assessed with the MDI at 2 years of age.

Results:  The mean MDI in VLBW infants was 101.7 (SD 15.4), which was lower compared with FT controls (109.8, SD 11.7, p < 0.001). In regression analysis of the demographic and medical data of VLBW infants, postnatal corticosteroids (p = 0.04), intestinal perforation (p = 0.03) and major brain pathology (p = 0.02) were negatively associated with the MDI. In VLBW infants, the prevalence of neurodevelopmental impairment was 9.9% (3.3% MDI below 70, 7.1% cerebral palsy, 2.2% hearing aid, no blind infants).

Conclusion:  Cognitive development of VLBW infants seemed to have improved in comparison with earlier publications, but it differed from the FT controls. Neonatal factors affected cognitive development. Therefore, updated regional follow-up data are important for clinicians.

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