Vitamin D status and acute lower respiratory infection in early childhood in Sylhet, Bangladesh
Article first published online: 9 NOV 2009
© 2009 The Author(s)/Journal Compilation © 2009 Foundation Acta Pædiatrica
Volume 99, Issue 3, pages 389–393, March 2010
How to Cite
Roth, D., Shah, R., Black, R. and Baqui, A. (2010), Vitamin D status and acute lower respiratory infection in early childhood in Sylhet, Bangladesh. Acta Paediatrica, 99: 389–393. doi: 10.1111/j.1651-2227.2009.01594.x
- Issue published online: 1 FEB 2010
- Article first published online: 9 NOV 2009
- Received 15 June 2009; revised 19 September 2009; accepted 16 October 2009.
- Case–control study;
- Developing countries;
- Respiratory infections;
- Vitamin D
Aim: Acute lower respiratory tract infection (ALRI) is the most important global cause of childhood death. Micronutrient deficiencies may increase the risk of ALRI. A case–control study was conducted to assess the association between vitamin D status and ALRI in rural Bangladesh.
Methods: Children aged 1–18 months hospitalized with ALRI (cases) were individually matched to controls on age, sex, and village (N = 25 pairs). The mean serum 25-hydroxyvitamin D concentration [25(OH)D] in cases and controls was compared using paired t-test. The unadjusted and adjusted odds of ALRI were assessed by multivariate conditional logistic regression.
Results: Mean [25(OH)D] was significantly lower among ALRI cases than controls (29.1 nmol/L vs. 39.1 nmol/L; p = 0.015). The unadjusted odds of ALRI was halved for each 10 nmol/L increase in [25(OH)D] (OR 0.53, 95% CI 0.30–0.96). Adjustment for confounders increased the magnitude of the association.
Conclusion: Vitamin D status was associated with early childhood ALRI in a matched case–control study in rural Bangladesh. Randomized trials may establish whether interventions to improve vitamin D status can reduce the burden of ALRI in early childhood.