Earlier versus later continuous Kangaroo Mother Care (KMC) for stable low-birth-weight infants: a randomized controlled trial
Article first published online: 27 JAN 2010
© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Pædiatrica
Volume 99, Issue 6, pages 826–835, June 2010
How to Cite
Nagai, S., Andrianarimanana, D., Rabesandratana, N., Yonemoto, N., Nakayama, T. and Mori, R. (2010), Earlier versus later continuous Kangaroo Mother Care (KMC) for stable low-birth-weight infants: a randomized controlled trial. Acta Paediatrica, 99: 826–835. doi: 10.1111/j.1651-2227.2009.01676.x
- Issue published online: 4 MAY 2010
- Article first published online: 27 JAN 2010
- Received 20 July 2009; revised 9 December 2009; accepted 11 December 2009.
- Kangaroo mother care;
- Randomized controlled trial;
- Resource-limited country
Aim: The aim of this study was to examine the effectiveness of earlier continuous Kangaroo Mother Care (KMC) for relatively stable low-birth-weight (LBW) infants in a resource-limited country.
Methods: A randomized controlled trial was performed in LBW infants at a referral hospital in Madagascar. Earlier continuous KMC (intervention) was begun as soon as possible, within 24 h postbirth, and later continuous KMC (control: conventional care) was begun after complete stabilization (generally after 24 h postbirth). Main outcome measure was mortality during the first 28 days postbirth. This trial was registered with ClinicalTrials.gov, NCT00531492.
Results: A total of 73 infants (intervention 37, control 36) were included. Earlier continuous KMC had higher but no statistically different mortality in the first 28 days postbirth (1 vs. 2; risk ratio, 1.95; 95% CIs, 0.18–20.53; p = 1.00). There were no differences in incidence of morbidities. Body weight loss from birth to 24 h postbirth was significantly less in earlier KMC infants compared with later KMC infants. (−34.81 g vs. −73.97 g; mean difference, 39.16 g; 95% CIs, 10.30–68.03; p = 0.01; adjusted p = 0.02). Adverse events and duration of hospitalization were not different between the two groups.
Conclusions: Further evaluations of earlier continuous KMC including measurement of KMC dose, are needed in resource-limited countries.