These authors contributed equally to this study.
Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year prospective study
Article first published online: 16 FEB 2010
© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Pædiatrica
Volume 99, Issue 6, pages 883–887, June 2010
How to Cite
Calvo, C., Pozo, F., García-García, M., Sanchez, M., Lopez-Valero, M., Pérez-Breña, P. and Casas, I. (2010), Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year prospective study. Acta Paediatrica, 99: 883–887. doi: 10.1111/j.1651-2227.2010.01714.x
This work was supported by Spanish National Health Institute (ISCIII, Fondo de Investigaciones Sanitarias) Grants 98/0310 and PI06/0532.
- Issue published online: 4 MAY 2010
- Article first published online: 16 FEB 2010
- Received 21 September 2009; revised 1 December 2009; accepted 13 January 2010
- Human bocavirus;
- Human metapneumovirus;
- Respiratory syncytial virus;
Aim: We have designed a study with the objective of describing the clinical impact of other viruses different from the respiratory syncytial virus (RSV) in hospitalized infants with bronchiolitis.
Methods: A 3 year prospective study was conducted on infants admitted to the Paediatrics Department of the Severo Ochoa Hospital (Spain). We studied the frequency of 16 respiratory viruses. Clinical characteristics of RSV-only infections were compared with other single agent viral infections.
Results: Positive results were confirmed in 275 (86.5%) of the 318 children studied. A single virus was detected in 196 patients and 79 were dual or multiple viral infections. RSV was detected in 61.3% of total bronchiolitis. Rhinovirus (RV) was 17.4% of the identified virus, followed by human bocavirus (HBoV), adenovirus and metapneumovirus (hMPV). Only RV, HBoV and hMPV were significant as single infections. RSV patients were younger than HBoV (p > 0.0001) and hMPV (p = 0.025). Seasonality was clearly different between them. Children with RSV infection needed treatment in the intensive care unit more frequently than others.
Conclusions: In hospitalized infants, RSV was the most frequent agent in bronchiolitis in winter, but other viruses were present in 47% of the patients. RV, HBoV and hMPV had a significant proportion of single infections. Clinical characteristics were similar amongst them, but seasonality was clearly different.