Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth
Article first published online: 24 FEB 2010
© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Pædiatrica
Volume 99, Issue 6, pages 896–899, June 2010
How to Cite
Al-Attas, O., Al-Daghri, N., Bamakhramah, A., Shaun Sabico, S., McTernan, P. and Huang, T.-K. (2010), Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth. Acta Paediatrica, 99: 896–899. doi: 10.1111/j.1651-2227.2010.01720.x
- Issue published online: 4 MAY 2010
- Article first published online: 24 FEB 2010
- Received 28 September 2009; revised 13 January 2010; accepted 18 January 2010.
- Body-mass index;
- Insulin resistance;
- Obese children
Aim: The aim of this study was to determine the associations of telomere length to markers of obesity, insulin resistance and inflammation in Saudi children.
Methods: A total of 69 boys and 79 girls, aged 5–12 years, participated in this cross-sectional study. Anthropometrics were measured. Serum glucose and lipid profile were measured using routine laboratory methods. Serum insulin, leptin, adiponectin, resistin, tumour necrosis factor-alpha and active plasminogen activator inhibitor 1 were quantified using customized multiplex assay kits. C-reactive protein and angiotensin II were quantified using ELISA. Leucocyte telomere length was examined by quantitative real time PCR utilizing IQ cycler.
Results: Mean telomere length was significantly shorter in obese boys compared with their lean counterparts (p = 0.049), not in girls. It was not associated to insulin resistance, adipocytokines and markers of inflammation. In girls, the significant predictor of telomere length was waist circumference, explaining 24% of variance (p = 0.041) while in boys, systolic blood pressure explained 84% of the variance (p = 0.01).
Conclusion: Childhood obesity in boys corresponds to shorter leucocyte telomere length which is not evident in girls. The association of leucocyte telomere length to blood pressure and waist circumference in children suggests clinical implications as to the contribution of these parameters in premature ageing.