Recognition and treatment of genitourinary complications in paediatric Crohn’s disease using Infliximab

Authors


Nadeem Ahmad Afzal, Room EG244, Mailpoint 44, Southampton University Hospital NHS Trust, Tremona Road, Southampton SO16 6YD, Southampton, UK.
Tel: +44 2380 79 6489 | Fax: +44 2380 986 837 | Email: N.Afzal@soton.ac.uk

Abstract

Although genitourinary complications of Crohn’s are well recognized, available information regarding their clinical course and management is sparse especially in the paediatric population. We report a myriad of urological complications in five paediatric cases, our experience from a tertiary paediatric urological and gastroenterological centre. All children with urological complications had severe Crohn’s disease which necessitated the use of immuno-suppressants including Infliximab. Three of four children healed and closed their fistulas after treatment, although failed to avoid future surgery, albeit for other reasons.

Conclusion:  We suggest Infliximab should be considered as a treatment option but in the absence of a common consensus, treatment be tailored to individual cases.

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