Prevalence and risk factors of suppurative complications in children with pneumonia
Article first published online: 19 FEB 2010
© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Pædiatrica
Volume 99, Issue 6, pages 861–866, June 2010
How to Cite
François, P., Desrumaux, A., Cans, C., Pin, I., Pavese, P. and Labarère, J. (2010), Prevalence and risk factors of suppurative complications in children with pneumonia. Acta Paediatrica, 99: 861–866. doi: 10.1111/j.1651-2227.2010.01734.x
- Issue published online: 4 MAY 2010
- Article first published online: 19 FEB 2010
- Received 13 October 2009; revised 1 December 2009; accepted 22 January 2010.
- Community-acquired pneumonia;
- Lung abscess;
- Pleural empyema
Aim: To identify the baseline characteristics associated with suppurative complications in children with community-acquired primary pneumonia.
Methods: A retrospective study included all children from 28 days to 15 years old, who presented with community-acquired pneumonia at two French hospitals from 1995 to 2003. Complicated pneumonia was defined by the presence of empyema and/or lung abscess.
Results: Of 767 children with community-acquired pneumonia, 90 had suppurative complications: 83 cases of pleural empyema and seven cases of lung abscess. The mean prevalence of complicated pneumonia was 3% during the 1995–1998 period, and then steadily increased following a linear trend to reach 23% in 2003. Children with complicated pneumonia were older and had a longer symptomatic period preceding hospitalization. They were more likely to receive antibiotics, especially aminopenicillins (p < 0.01), and nonsteroidal anti-inflammatory drugs, especially ibuprofen (p < 0.001). In multivariable analysis, ibuprofen was the only preadmission therapy that was independently associated with complicated pneumonia [adjusted OR = 2.57 (1.51–4.35)].
Conclusion: This study confirms an association between the use of prehospital ibruprofen and suppurative pneumonic complications.