Paracetamol in early infancy: the risk of childhood allergy and asthma
Article first published online: 8 JUL 2010
© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Pædiatrica
Volume 100, Issue 1, pages 90–96, January 2011
How to Cite
Bakkeheim, E., Mowinckel, P., Carlsen, K. H., Håland, G. and Carlsen, K. C. L. (2011), Paracetamol in early infancy: the risk of childhood allergy and asthma. Acta Paediatrica, 100: 90–96. doi: 10.1111/j.1651-2227.2010.01942.x
- Issue published online: 8 DEC 2010
- Article first published online: 8 JUL 2010
- Received 22 February 2010; revised 1 June 2010; accepted 1 July 2010.
- Allergic sensitization;
Aim: We investigated whether paracetamol exposure in pregnancy and until 6 months of age was associated with allergic disease in school children.
Methods: In a prospective birth cohort study in Oslo, 1016 children included at birth were re-investigated at 10 years. Paracetamol exposure in pregnancy and until 6 months of age was registered. Outcomes at 10 years included current asthma, a history of asthma, allergic sensitization and allergic rhinitis.
Results: Maternal paracetamol use in the first trimester increased the risk for allergic rhinitis at 10 years OR (odds ratio) (95%CI) 2.30 (1.06, 4.97) in boys and girls. Paracetamol use until 6 months in girls increased the risk for allergic sensitization OR 2.20 (1.15, 4.22) and a history of asthma OR 2.20 (1.13, 4.30). The ORs for allergic sensitization and history of asthma in girls remained unchanged adjusting for upper or lower airway infections during the first 6 months of life.
Conclusion: Paracetamol exposure in pregnancy was associated with allergic rhinitis, but not with asthma or allergic sensitization at 10 years of age. Paracetamol used until 6 months of age was associated with allergic sensitization and having a history of asthma in girls at 10 years of age, even considering concomitant airway infections.