Paediatric Hashimoto encephalopathy, refractory epilepsy and immunoglobulin treatment – unusual case report and review of the literature


  • The authors have no conflicts of interest to disclose with regard to this study.

Itai Berger, M.D., The Neuro-Pediatric Unit, Hadassah-Hebrew University Medical Center, Mount Scopus, PO Box 24035, Jerusalem, 91240 Israel.
Tel: 972-2-5844751 |
Fax: 972-2-5328963 |


Background:  Hashimoto encephalopathy (HE) is a rare autoimmune disorder. It is defined as a ‘corticosteroid-responsive encephalopathy associated with thyroiditis’.

Clinical observation:  We describe a boy who suffered from HE, responded only to intravenous immunoglobulin therapy. This is the first case report of immunoglobulin therapy in paediatric HE.

Conclusion:  After review of the literature, we recommend that unexplained encephalopathy in children should lead to evaluation of thyroid autoantibody titres. Immunoglobulins should be considered.