Placental IGF-I, IGFBP-1, zinc, and iron, and maternal and infant anthropometry at birth
Article first published online: 25 MAY 2011
© 2011 The Author(s)/Acta Pædiatrica © 2011 Foundation Acta Pædiatrica
Volume 100, Issue 11, pages 1504–1509, November 2011
How to Cite
Akram, S. K., Carlsson-Skwirut, C., Bhutta, Z. A. and Söder, O. (2011), Placental IGF-I, IGFBP-1, zinc, and iron, and maternal and infant anthropometry at birth. Acta Paediatrica, 100: 1504–1509. doi: 10.1111/j.1651-2227.2011.02336.x
- Issue published online: 10 OCT 2011
- Article first published online: 25 MAY 2011
- Accepted manuscript online: 4 MAY 2011 01:44AM EST
- Received 10 June 2010; revised 28 February 2011; accepted 26 April 2011.
- Insulin-like growth factor binding protein-1;
- Insulin-like growth factor-1;
- Large for gestational age;
- Small for gestational age;
Aim: To correlate placental protein levels of insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-1, with previously determined levels of IGF-I and IGF-II mRNA expression, and the micronutrients zinc and iron, and maternal and newborn anthropometry.
Methods: Placental samples were collected from rural field sites in Pakistan. Samples were divided into small and large for gestational age groups (SGA and LGA, respectively). IGFBP-1 levels were assessed using Western immunoblotting. IGF-I protein levels were assessed using ELISA techniques. IGF mRNA expression, zinc, and iron, were quantified as previously described and were used for comparative purposes only.
Results: Thirty-three subjects were included (SGA, n = 12; LGA n = 21). Higher levels of IGFBP-1 were seen in the SGA group (p < 0.01). IGFBP-1 correlated positively with maternal and infant triceps skin-fold thickness in the LGA and SGA groups, respectively (p < 0.05). Significantly lower IGF-I protein levels were seen in the SGA group. IGF-I levels correlated significantly with maternal and newborn anthropometry. IGFBP-1 correlated significantly with IGF-II mRNA expression (p < 0.05).
Conclusion: Placental protein levels of IGF-I and IGFBP-1 appear to be associated with maternal anthropometry. Maternal anthropometry may thus influence IGFBP-1 and IGF-I levels and may possibly be used for screening of pregnancies, with the potential for timely identification of these high-risk pregnancies.