Maternal and neonatal factors associated with poor early weight gain and later retinopathy of prematurity
Version of Record online: 18 JUL 2011
© 2011 The Author(s)/Acta Pædiatrica © 2011 Foundation Acta Pædiatrica
Volume 100, Issue 12, pages 1528–1533, December 2011
How to Cite
Wikstrand, M. H., Hård, A.-L., Niklasson, A., Smith, L., Löfqvist, C. and Hellström, A. (2011), Maternal and neonatal factors associated with poor early weight gain and later retinopathy of prematurity. Acta Paediatrica, 100: 1528–1533. doi: 10.1111/j.1651-2227.2011.02394.x
- Issue online: 8 NOV 2011
- Version of Record online: 18 JUL 2011
- Accepted manuscript online: 4 JUL 2011 12:35PM EST
- Received 21 April 2011; revised 16 June 2011; accepted 28 June 2011
- Retinopathy of prematurity;
Aim: To identify factors associated with poor early weight gain as reflected in an alarm system, WINROP, and risk of later proliferative retinopathy of prematurity (ROP) in infants with gestational age (GA) < 28 weeks.
Methods: Infants with a WINROP alarm and proliferative ROP, the ‘alarm group’ (n = 23), were matched to GA and gender to a ‘no alarm group’ (n = 23) with no WINROP alarm and no or mild ROP. Retrospectively maternal variables, birth characteristics and neonatal factors, during the first three postnatal weeks, were compared.
Results: The ‘alarm group’ had lower birth weight (BW) and BW standard deviation score, longer stay in ventilator, more insulin and corticosteroid treatments, and lower white blood cell count. In a logistic regression model, BW standard deviation score, insulin, low white blood cell count, absence of both elevated C-reactive protein and premature rupture of membranes were associated with proliferative ROP and WINROP alarm (p = 0.000, r2 = 0.704).
Conclusions: This study shows that prenatal factors resulting in low BW have persisting effects on early postnatal growth, metabolism and inflammatory response. Future prospective studies will focus on the link between these factors and pathological retinal vessel development in the early postnatal period to find possible preventive strategies.