Coeliac disease in children: a social epidemiological study in Sweden
Article first published online: 7 SEP 2011
© 2011 The Author(s)/Acta Pædiatrica © 2011 Foundation Acta Pædiatrica
Volume 101, Issue 2, pages 185–191, February 2012
How to Cite
Wingren, C. J., Björck, S., Lynch, K. F., Ohlsson, H., Agardh, D. and Merlo, J. (2012), Coeliac disease in children: a social epidemiological study in Sweden. Acta Paediatrica, 101: 185–191. doi: 10.1111/j.1651-2227.2011.02434.x
- Issue published online: 9 JAN 2012
- Article first published online: 7 SEP 2011
- Accepted manuscript online: 8 AUG 2011 12:19PM EST
- Received 24 May 2011; revised 12 July 2011; accepted 1 August 2011.
- Coeliac disease;
- Risk factors;
- Socioeconomic factors
Aim: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two.
Methods: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792 401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics.
Results: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03–1.82), but not in girls OR 0.87 (95% CI 0.68–1.12). We found a considerable geographical variation in disease risk (i.e. intra-municipality correlation ≈ 10%) that was not explained by individual characteristics.
Conclusions: Low SEP is associated with CD in boys but not in girls. Also, CD appears to be conditioned by geographical area of residence. While our study represents an innovative contribution to the epidemiology of CD in children, the reasons for the observed geographical and socioeconomic differences could be speculated but are still unknown.