Development of smooth pursuit eye movements in very preterm born infants: 3. Association with perinatal risk factors
Article first published online: 23 SEP 2011
© 2011 The Author(s)/Acta Pædiatrica © 2011 Foundation Acta Pædiatrica
Volume 101, Issue 2, pages 164–171, February 2012
How to Cite
Strand Brodd, K., Grönqvist, H., Holmström, G., Grönqvist, E., Rosander, K. and Ewald, U. (2012), Development of smooth pursuit eye movements in very preterm born infants: 3. Association with perinatal risk factors. Acta Paediatrica, 101: 164–171. doi: 10.1111/j.1651-2227.2011.02449.x
- Issue published online: 9 JAN 2012
- Article first published online: 23 SEP 2011
- Accepted manuscript online: 24 AUG 2011 06:16AM EST
- Received 19 May 2011; revised 17 August 2011; accepted 18 August 2011.
- Neurodevelopmental outcome;
- Perinatal risk factors;
- Preterm infants;
- Smooth pursuit eye;
- Visual development
Aim: To investigate the association between perinatal risk factors and neonatal complications and early oculo-motor development in very preterm infants.
Methods: Perinatal risk factors were identified, and the potential association with early oculo-motor development was evaluated by measuring smooth pursuit eye movements (SP) at 2 and 4 months’ corrected age (CA) in a population of very preterm infants born in Uppsala County 2004–2007 (n = 113).
Results: Among the 15 tested factors, eight showed significant association in univariate analysis with lower levels of SP at 4 months’ CA, namely administration of prenatal corticosteroids, gestational age, birthweight, bronchopulmonary dysplasia, retinopathy of prematurity, periventricular leukomalacia, intraventricular haemorrhage >grade 2, and persistent ductus arteriosus. At 2 months’ CA, only retinopathy of prematurity >stage 2 was associated with lower levels of SP. When all factors significant in the univariate tests were included in multiple regressions aimed to assess each factor’s independent relation to SP, periventricular leukomalacia was the only significant independent factor. When adding 2–5 of the significant factors using multiple regression analysis, the levels of SP became lower.
Conclusion: Perinatal risk factors were associated with lower levels of SP. This could be interpreted as delayed or disturbed development of normal oculomotor ability.