REGULAR ARTICLE

Serum S100B and neuron-specific enolase levels in normothermic and hypothermic infants after perinatal asphyxia

  1. Aniko Roka1,2,
  2. Dorottya Kelen2,
  3. Jozsef Halasz3,
  4. Gabriella Beko4,
  5. Denis Azzopardi1,5,
  6. Miklos Szabo2

Article first published online: 2 NOV 2011

DOI: 10.1111/j.1651-2227.2011.02480.x

Issue

Acta Paediatrica

Acta Paediatrica

Volume 101, Issue 3, pages 319–323, March 2012

Additional Information

How to Cite

Roka, A., Kelen, D., Halasz, J., Beko, G., Azzopardi, D. and Szabo, M. (2012), Serum S100B and neuron-specific enolase levels in normothermic and hypothermic infants after perinatal asphyxia. Acta Paediatrica, 101: 319–323. doi: 10.1111/j.1651-2227.2011.02480.x

Author Information

  1. 1

    .Neonatal Unit, Queen Charlotte’s and Chelsea Hospital, London, UK

  2. 2

    .First Department of Pediatrics, Semmelweis University, Budapest, Hungary

  3. 3

    .Vadaskert Child Psychiatry Hospital, Budapest, Hungary

  4. 4

    .First Department of Medicine, Semmelweis University, Budapest, Hungary

  5. 5

    .Centre for Developing Brain, Imperial College London, London, UK

*A Roka, Queen Charlotte’s and Chelsea Hospital, Neonatal Unit, DuCane Road, London W12 0HS, UK. Tel: +44 7514971251 | Fax: +44 2083835139 | Email: aniko.roka@gmail.com

  1. The authors have no relationships/conditions/circumstances that present a potential conflict of interest.

  2. The TOBY trial was supported by the United Kingdom Medical Research Council and the Department of Health.

Publication History

  1. Issue published online: 25 JAN 2012
  2. Article first published online: 2 NOV 2011
  3. Accepted manuscript online: 7 OCT 2011 08:39AM EST
  4. Received 30 June 2011; revised 25 August 2011; accepted 3 October 2011.
Corrected by:

CORRIGENDUM

Vol. 101, Issue 11, 1184, Article first published online: 1 OCT 2012

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Keywords:

  • Asphyxia;
  • Hypothermia;
  • NSE;
  • S100B

Abstract

Aim:  Serum S100B and neuron-specific enolase (NSE) levels are elevated after perinatal asphyxia, but the influence of hypothermia on these proteins has not been previously reported. The aim of this study was to evaluate the effect of systemic hypothermia on these protein levels after perinatal asphyxia, time course, and association with perinatal factors and neurodevelopmental outcome at 2 years of age.

Methods:  Serum S100B and NSE levels were measured at fixed time points in asphyxiated infants treated with standard intensive care on hypothermia (HT: n = 13) or normothermia (NT: n = 11).

Results:  Serum S100B and NSE levels were grossly elevated in both HT and NT groups. Compared with the values at 6 h of age, S100B values decreased over time in both groups (NT: p = 0.002, HT: p = 0.04). Serum S100B values were lower in HT infants compared with those in NT infants (p = 0.047 at 48 h). Serum S100B and NSE values were significantly higher in infants who died or developed severe neurological impairment (S100B, p < 0.05 at all time points; NSE, p = 0.036 at 24 h of age).

Conclusion:  Both NSE and S100B levels are highly elevated following asphyxia. Serum S100B levels were lower in the HT group and strongly correlated with the neurodevelopmental outcome.

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