The developing immune system – from foetus to toddler
Article first published online: 10 NOV 2011
© 2011 The Author(s)/Acta Pædiatrica © 2011 Foundation Acta Pædiatrica
Volume 101, Issue 2, pages 120–127, February 2012
How to Cite
Ygberg, S. and Nilsson, A. (2012), The developing immune system – from foetus to toddler. Acta Paediatrica, 101: 120–127. doi: 10.1111/j.1651-2227.2011.02494.x
- Issue published online: 9 JAN 2012
- Article first published online: 10 NOV 2011
- Accepted manuscript online: 17 OCT 2011 11:29AM EST
- Received 1 June 2011; revised 19 September 2011; accepted 12 October 2011.
- Infant development;
- Infectious diseases
During foetal development, neonatal period and childhood, the immune system is constantly maturing. In the foetus, infection responsiveness is low and associates with spontaneous abortion. During the neonatal period, the infection response shifts towards a more pro-inflammatory response. The immune system of the newborn acquires adaptive features as a result of exposure to microbes.
Conclusion: The development of the human immune system is a continuous process where both accelerated and retarded development is deleterious.