An evidence-based view on hyperbilirubinaemia


Peter H. Dijk, M.D., PhD., Division of Neonatology, Beatrix Children’s Hospital, University Medical Center Groningen, Hanzeplein 1, PO Box 30.001, 9713 GZ Groningen, The Netherlands. Tel: +31 50 361 42 15 | Fax: +31 50 361 42 35 | Email:


Introduction:  We conducted a review of the evidence which contributes to the current care of jaundiced newborn infants.

Methods:  Literature was searched for reviews and randomized controlled trials (RCTs).

Results:  Six Cochrane reviews and eight other reviews and eighteen recent RCTs are discussed.

Conclusions:  Many children still suffer life-long consequences of severe hyperbilirubinaemia, which could almost always have been prevented relatively easily. Up to date, guidelines summarizing the available evidence into unambiguous recommendations are needed to guide healthcare professionals in the prevention, diagnosis and treatment for infants with hyperbilirubinaemia.