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Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 3A

Authors

  • Jean-Sébastien Joyal,

    1. .Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montréal, QC, Canada
    2. .Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada
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    • These authors contributed equivalently to this work.

  • Samy Omri,

    1. .Department of Ophthalmology, Hôpital Maisonneuve-Rosemont Research Center, Montréal, QC, Canada
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    • These authors contributed equivalently to this work.

  • Nicholas Sitaras,

    1. .Department of Ophthalmology, Hôpital Maisonneuve-Rosemont Research Center, Montréal, QC, Canada
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  • José-Carlos Rivera,

    1. .Department of Ophthalmology, Hôpital Maisonneuve-Rosemont Research Center, Montréal, QC, Canada
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  • Przemyslaw Sapieha,

    1. .Department of Ophthalmology, Hôpital Maisonneuve-Rosemont Research Center, Montréal, QC, Canada
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  • Sylvain Chemtob

    1. .Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montréal, QC, Canada
    2. .Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada
    3. .Department of Ophthalmology, Hôpital Maisonneuve-Rosemont Research Center, Montréal, QC, Canada
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Sylvain Chemtob, M.D., Ph. D. or Przemyslaw Sapieha, Ph.D., Hôpital Maisonneuve-Rosemont Research Center, 5415 L’Assomption, Montréal, Québec H1T 2M4, Canada. Tel: (514) 345-4931 #2978 | Fax: (514) 345-4801 |
Email: sylvain.chemtob@umontreal.ca; mike.sapieha@umontreal.ca

Abstract

Retinopathy of prematurity (ROP) is a major cause of severe visual deficits in children. This review focuses on the role of newly identified factors from retinal neurons, which through their opposing actions on vascular development contribute to ROP. These hypoxia-generated mediators include the Krebs cycle intermediate, succinate acting via GPR91, and the neuronal guidance molecule Semaphorin 3A.Conclusion: Neuron-derived factors guide retinal vascularization and are major contributors to the pathogenesis of ROP.

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