Simultaneous occurrence of foetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature

Authors


E Taaning, M.D., DMSc, Department of Clinical Immunology, Tissue Typing Laboratory, section 7631, Rigshospitalet, University of Copenhagen, 20 Tagensvej, DK-2200 Copenhagen N, Denmark. Tel: +45-35-45-73-76/+45-35-45-76-31 | Fax: +45-35-39-87-66 | E-mails: ellen.morling.taaning@rh.regionh.dk or ellen.taaning@dadlnet.dk

Abstract

Foetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal neutropenia caused by maternal autoantibodies against neutrophils are rare disorders. We describe a newborn with severe thrombocytopenia and intracerebral bleeding caused by maternal anti-HPA-3a alloantibodies and mild neutropenia caused by maternal autoantibodies against HNA-1b. This appears to be the first case of simultaneous occurrence of these two conditions.

Conclusion:  This case report and review of the literature demonstrate that anti-HPA-3a antibodies can be overlooked by standard assays.

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