Maternal dietary fat and fatty acid intake during lactation and the risk of asthma in the offspring
Article first published online: 18 MAY 2012
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica
Volume 101, Issue 8, pages e337–e343, August 2012
How to Cite
Lumia, M., Luukkainen, P., Kaila, M., Tapanainen, H., Takkinen, H.-M., Prasad, M., Niinistö, S., Nwaru, B. I., Kenward, M. G., Ilonen, J., Simell, O., Knip, M., Veijola, R. and Virtanen, S. M. (2012), Maternal dietary fat and fatty acid intake during lactation and the risk of asthma in the offspring. Acta Paediatrica, 101: e337–e343. doi: 10.1111/j.1651-2227.2012.02718.x
- Issue published online: 13 JUL 2012
- Article first published online: 18 MAY 2012
- Accepted manuscript online: 11 MAY 2012 12:25PM EST
- Received 9 November 2011; revised 19 April 2012; accepted 20 April 2012.
- Fat intake;
Aim: To explore the association between maternal dietary fat and fatty acid (FA) intake during lactation, and the risk of asthma in the offspring by the age of 5 years.
Methods: The subjects comprised 1798 mother–child pairs from the Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study. Dietary intake was assessed by a validated 181-item food frequency questionnaire, which covered the third month of lactation. The cumulative incidence of asthma was assessed at the age of 5 years with a questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC). Cox proportional hazards regression was used for statistical analysis.
Results: The maternal use of margarines during lactation was associated with a marginally increased risk of asthma [hazard ratio (HR) for user vs. nonuser 1.96, 95% confidence interval (CI) 1.01–3.82, p = 0.047] after adjusting for putative confounders. The maternal intakes of n-3 polyunsaturated FA (PUFA) and fish during lactation were not associated with the risk of asthma.
Conclusion: Maternal use of margarines during lactation was weakly associated with an increased risk of asthma in the offspring at the age of 5 years. Other fats or FAs during lactation were not associated with the risk of asthma. However, the nonadherence to dietary recommendations regarding especially fats of our study population may restrict the generalizability of our results.