Adiponectin in breast milk: relation to serum adiponectin concentration in lactating mothers and their infants
Article first published online: 12 JUL 2012
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica
Volume 101, Issue 10, pages 1058–1062, October 2012
How to Cite
Savino, F., Lupica, M., Benetti, S., Petrucci, E., Liguori, S. and Cordero Di Montezemolo, L. (2012), Adiponectin in breast milk: relation to serum adiponectin concentration in lactating mothers and their infants. Acta Paediatrica, 101: 1058–1062. doi: 10.1111/j.1651-2227.2012.02744.x
- Issue published online: 29 AUG 2012
- Article first published online: 12 JUL 2012
- Accepted manuscript online: 30 MAY 2012 10:16AM EST
- Received20 January 2012; revised 4 May 2012; accepted 21 May 2012.
- Breastfed infants;
- Human milk;
- Lactating mothers
Aims: The aims of the study were to determine human breast milk adiponectin concentration and to investigate its relationship with serum adiponectin concentration in lactating mothers and their infants and also to evaluate the relationship between serum adiponectin concentration and anthropometric parameters in nurses and infants.
Methods: We enrolled 60 healthy term breastfed (BF) infants and their lactating mothers. Adiponectin was determined by radioimmunoassay test in serum and by enzyme-linked immunosorbent assay test in human milk (HM). Infants’ and mothers’ anthropometric parameters were measured.
Results: Median (25‰, 75‰) adiponectin concentration in HM was 9.99 (3.59, 20.52) ng/mL. Serum adiponectin concentration in infants was 60.49 (45.76, 74.24) μg/mL and in lactating mothers 21.14 (12.61, 29.66) μg/mL. Adiponectin concentration in HM correlated positively with adiponectin in mothers’ serum; r = 0.60 (p < 0.001) and in infants’ serum r = 0.37 (p = 0.015). Adiponectin in HM correlated negatively with infants’ age r = −0.3 (p = 0.04). Infants’ serum adiponectin correlated negatively with their weight r = −0.35 (p = 0.005), length r = −0.35 (p = 0.006) and age r = −0.46 (p < 0.001) and mothers’ serum adiponectin with their weight r = −0.37 (p = 0.02) and body mass index r = −0.45 (p = 0.004).
Conclusions: The observed correlations between adiponectin in mothers, HM and BF infants may be suggestive for a metabolic link between nurses and infants through milk.