Swedish Medical Products Agency Reg #: ISI: 2003-57143.
Tacrolimus without or with the addition of conventional immunosuppressive treatment in juvenile autoimmune hepatitis
Article first published online: 19 JUN 2012
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica
Volume 101, Issue 9, pages 993–999, September 2012
How to Cite
Marlaka, J. R., Papadogiannakis, N., Fischler, B., Casswall, T. H., Beijer, E. and Németh, A. (2012), Tacrolimus without or with the addition of conventional immunosuppressive treatment in juvenile autoimmune hepatitis. Acta Paediatrica, 101: 993–999. doi: 10.1111/j.1651-2227.2012.02745.x
- Issue published online: 3 AUG 2012
- Article first published online: 19 JUN 2012
- Accepted manuscript online: 30 MAY 2012 10:17AM EST
- Received 30 November 2011; revised 16 May 2012; accepted 21 May 2012.
Figure S1 Changes in the excretion of tacrolimus from thestart of the treatment (blue bars) the end of the year (redbars), expressed as the ratio between blood concentration(ng /mL) and given dose (mg / kg per day). Pat #1 discontinuedTac 10 months after start of treatment.
Figure S2 Course of serum alanine aminotransferase concentrationsduring 1 year of treatment. (a) In seven patientswith Tacrolimus monotherapy. (b) In 13 patients with combinationtherapy.
Figure S3 Change in glomerular filtration rate during thetreatment period measured by iohexol clearance at start(blue) and after 1 year (red).
Table S1 Baseline characteristics of the patients included,listed according to their age at inclusion.
Table S2 Main clinical events and immunosuppressive medicationother than tacrolimus during the one-year treatmentperiod and outcome.
Table S3 Changes in the histological pattern between thebaseline and the follow-up biopsies in 14 of the 20 patients.
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