Propranolol treatment for severe infantile hemangiomas: a single-centre 3-year experience
Article first published online: 24 JUL 2012
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica
Volume 101, Issue 10, pages e469–e474, October 2012
How to Cite
Georgountzou, A., Karavitakis, E., Klimentopoulou, A., Xaidara, A. and Kakourou, T. (2012), Propranolol treatment for severe infantile hemangiomas: a single-centre 3-year experience. Acta Paediatrica, 101: e469–e474. doi: 10.1111/j.1651-2227.2012.02783.x
- Issue published online: 29 AUG 2012
- Article first published online: 24 JUL 2012
- Accepted manuscript online: 14 JUL 2012 10:10AM EST
- Received 26 March 2012; revised 30 June 2012; accepted 4 July 2012.
- Infantile hemangiomas;
- Propranolol treatment
Aim: To evaluate the effectiveness, safety and tolerability of propranolol as single-agent treatment in patients with problematic, proliferative-phase, infantile hemangiomas (IHs).
Methods: Oral propranolol was administered at a dose of 2 mg/kg/day to 28 children. Cardiologic evaluation was performed before treatment initiation. Hemodynamic variables and blood glucose levels were monitored during the first 24 h of treatment, while the children were hospitalized. Clinical response and tolerance were assessed every month, along with photographic documentation. Macroscopic regression was considered the reduction >90% in the size of the IHs.
Results: Effects on colour and growth were observed within the first month in all cases. Twenty-four patients completed treatment after a mean duration of 7.56 months, and their hemangiomas were successfully regressed. Propranolol was administered again, with satisfactory results, in three patients (12.5%) because of hemangioma regrowth. Satisfactory response is noticeable in ongoing cases. Episodes of hypotension were noted in four patients. There were no treatment interruptions because of side effects.
Conclusions: Propranolol, as first-line treatment, yielded excellent results with very good clinical tolerance and also seems to be effective in relapses. The optimal duration of the treatment remains to be defined by long-term observation.