Langerhans cell histiocytosis in children born 1982–2005 after in vitro fertilization
Article first published online: 11 SEP 2012
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica
Volume 101, Issue 11, pages 1151–1155, November 2012
How to Cite
Åkefeldt, S. O., Finnström, O., Gavhed, D. and Henter, J.-I. (2012), Langerhans cell histiocytosis in children born 1982–2005 after in vitro fertilization. Acta Paediatrica, 101: 1151–1155. doi: 10.1111/j.1651-2227.2012.02796.x
- Issue published online: 1 OCT 2012
- Article first published online: 11 SEP 2012
- Accepted manuscript online: 26 JUL 2012 12:05PM EST
- Received 26 April 2012; revised 5 July 2012; accepted 23 July 2012.
- In vitro fertilization;
- Langerhans cell histiocytosis;
Aim: In a recent Swedish study, comparing data from the Swedish Cancer Register with the Medical Birth Register including data on IVF, an increased risk of Langerhans cell histiocytosis (LCH) was found in children born 1982–2005 after IVF. Here, we aimed to verify the LCH diagnoses and examine whether any special forms of the disease were overrepresented in this population.
Methods: Medical records for all children with LCH conceived by IVF were acquired and the diagnosis confirmed or discarded. Disease characteristics were compared with data from children diagnosed with LCH 1992–2001 in the Stockholm County.
Results: We verified LCH in seven children born after IVF, all born prior to 2002. These children did not have milder disease forms. The odds ratio (OR) to develop LCH for the whole group born after IVF was 3.2 [95% confidence interval (CI), 1.4–7.3] and for children born before 2002, 5.2 [95% CI, 2.3–11.9], compared with children in Stockholm County 1992–2001.
Conclusion: LCH was overrepresented in children born after IVF prior to 2002. Affected children did not have milder disease forms. These findings may be valuable to understand LCH aetiology. Additional studies on a putative correlation between IVF and LCH in the offspring are encouraged.