Respiratory syncytial virus infection and chronic respiratory morbidity – is there a functional or genetic predisposition?
Article first published online: 11 SEP 2012
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica
Volume 101, Issue 11, pages 1114–1120, November 2012
How to Cite
Drysdale, S. B., Milner, A. D. and Greenough, A. (2012), Respiratory syncytial virus infection and chronic respiratory morbidity – is there a functional or genetic predisposition?. Acta Paediatrica, 101: 1114–1120. doi: 10.1111/j.1651-2227.2012.02825.x
- Issue published online: 1 OCT 2012
- Article first published online: 11 SEP 2012
- Accepted manuscript online: 29 AUG 2012 09:55AM EST
- Received 29 March 2012; revised 31 July 2012; accepted 14 August 2012.
- Lung function;
- Respiratory syncytial virus
A systematic literature review has been undertaken. Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) in infancy is associated with chronic respiratory morbidity. Premorbid abnormal lung function may predispose to RVS LRTI in prematurely born infants.
Conclusion: Single-nucleotide polymorphisms in genes coding for IL-8, IL-19, IL-20, IL-13 mannose-binding lectin, IFNG and a RANTES polymorphism have been associated with subsequent wheeze following RSV LRTI in term-born infants.